This page contains detailed information for all the specific research examples we've cited, as well as the general background. You can also find links here for you to visit ongoing research projects on the origin of replication.
Are you interested in studying this topic? The University of Nottingham in the UK has an active lab studying the origin of replication, that is currently accepting PhD students! Visit the page of Dr. Thorsten Allers to learn about the lab, and go here to see a detailed PhD project that the lab is currently seeking a student for.
Visit: A lab right here at NC State has a long-term project to discover where origins of replication are in both plants and the viruses that infect them. Check it out here.
The NSF maintains a searchable database of all projects it funds. To see how much money has been directed to studies on the origin of replication, with detailed links to each study, go here.
Primary literature The information on the history of research on DNA replication was drawn heavily from this review paper: -Holmes, F. (1998). The DNA replication problem, 1953-1958. Trends in Biological Sciences. 23, 117-120.
About replication and structure of the origin of replication: -Falaschi, A., & Giacca, M. (1994). The quest for a human ori. Genetica, 94, 225-266. -Nasheuer HP, Smith R, Bauerschmidt C, Grosse F, Weisshart K (2002). "Initiation of eukaryotic DNA replication: regulation and mechanisms". Prog. Nucleic Acid Res. Mol. Biol. 72: 41–94. -Nowinska, K.; Chmielewska, M.; Piotrowska, A.; Pula, B.; Pastuszewski, W.; Krecicki, T.; Podhorska-Okołow, M.; Zabel, M.; Dziegiel, P. (2016-02-01). "Correlation between levels of expression of minichromosome maintenance proteins, Ki-67 proliferation antigen and metallothionein I/II in laryngeal squamous cell cancer". International Journal of Oncology. 48 (2): 635–645.
Evolution: -Garavis, M., Gonzalez, C., & Villasante, A. (2013). On the Origin of the Eukaryotic Chromosome: The Role of Noncanonical DNA Structures in Telomere Evolution. Genome Biology and Evolution, 5(6), 1142–1150. -Gray, M. W. (2012). Mitochondrial Evolution. Cold Spring Harbor Perspectives in Biology, 4(9), a011403. Kunnimalaiyaan, M., & Nielsen, B. L. (1997). Chloroplast DNA Replication: Mechanism, Enzymes and Replication Origins. J. Plant Biochemistry & Biotechnology, 6(1), 1–7. -Nielsen, B. L., Cupp, J. D., & Brammer, J. (2010). Mechanisms for maintenance, replication, and repair of the chloroplast genome in plants. Journal of Experimental Botany, 61(10), 2535–7. -Oldenburg, D. J., & Bendich, A. J. (2004). Changes in the Structure of DNA Molecules and the Amount of DNA Per Plastid During Chloroplast Development in Maize. Journal of Molecular Biology, 344(5), 1311–1330. Oldenburg, D. J., & Bendich, A. J. (2015). DNA maintenance in plastids and mitochondria of plants. Frontiers in Plant Science, 6, 883.
Cancer: -Boyer, A. S., Walter, D., & Sørensen, C. S. 2016. DNA replication and cancer: From dysfunctional replication origin activities to therapeutic opportunities. In Seminars in cancer biology 37:.16-25 Academic Press. -Di Paola, D., Price, G. B., & Zannis-Hadjopoulos, M. (2006). Differentially active origins of DNA replication in tumor versus normal cells. Cancer research, 66: 5094-5103. -Evertts, A. G., & Coller, H. A. (2012). Back to the Origin Reconsidering Replication, Transcription, Epigenetics, and Cell Cycle Control. Genes & cancer, 3: 678-696. -Méchali, M. (2008). DNA Replication Origins, Development, and Cancer. In Hormonal Control of Cell Cycle: 1-10. Springer Berlin Heidelberg. -Mesner LD, Valsakumar V, Karnani N, Dutta A, Hamlin JL, Bekiranov S. (2011). Bubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcription. Genome Res. 21:377-89 -National Center for Health Statistics. Health, United States , 2015 :With Special Feature on Racial and Ethnic Health Disparities. Date accessed 11/18/2016. http://www.cdc.gov/nchs/data/hus/hus15.pdf#019 -Oppenheim A, Martin RG. (1978). Initiation points for DNA replication in nontransformed and simian virus 40-transformed BALB/c 3T3 cells. J Virol. 25: 450–2 -Tao L, Dong Z, Zannis-Hadjopoulos M, Price GB. (2001). Immortalization of human WI38 cells is associated with differential activation of the c-myc origins. J Cell Biochem. -Valenzuela, M. S., Hu, L., Lueders, J., Walker, R., & Meltzer, P. S. (2012). Broader utilization of origins of DNA replication in cancer cell lines along a 78 kb region of human chromosome 2q34. Journal of cellular biochemistry, 113. 132-140. -Bell, S.D., Mechali, M. & DePampbilis, M.L. “Mechali’s Lab Current Research.” Cold Spring Harbor Laboratory (2013). -Allers, Thorsten & Alexander, Conrad. “Life Without DNA Replication Origins.” Nature 503, 544-7 (2013).
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